LongiTech
COMING UP: lavaan based toolbox for longitudinal data analysis (including SEM-based cross-lag panel models, G estimation and longitudinal network analyses) | Repository
Posts by Collection
packages
GenR.helpR
A collection of functions to help load, clean, inspect, subset, transform and analyse Generation R datasets. | Repository
ALSPAC.helpR
A collection of functions to load, clean, inspect, subset, transform and analyse ALSPAC data. | Repository
verywise
A flexible, user-friendly interface to whole-brain surface (multilevel) analysis. | Repository
portfolio
Portfolio item number 1
Short description of portfolio item number 1
Portfolio item number 2
Short description of portfolio item number 2
publications
Attentional modulation of neural dynamics in tactile perception of complex regional pain syndrome patients
Defina at al. (2021); European Journal of Neuroscience
Tags: EEG Multivariate pattern analysis ("Brain decoding") Support vector machine (SVM) Temporal generalization analysis (TGA) Topographical mapping Signal detection theory (SDT)
Mapping gene by early life stress interactions on child subcortical brain structures: A genome-wide prospective study
Bolhuis, Mulder at al. (2022); Journal of Child Psychology and Psychiatry
Depression, cardiometabolic disease, and their co-occurrence after childhood maltreatment: an individual participant data meta-analysis including over 200,000 participants
Souama at al. (2023); BMC Medicine
Differential effects of pre- and postnatal early-Life stress on internalizing, adiposity, and their comorbidity
Defina at al. (2023); Journal of the American Academy of Child & Adolescent Psychiatry
Tags: Multi-cohort data harmonization Multiple imputation Causal inference Mediation analysis
Associations of Prenatal Maternal Depressive Symptoms with Cord Blood Glucocorticoids and Child Hair Cortisol Levels in the Project Viva and the Generation R Cohorts: A Prospective Cohort Study
Cohen at al. (2023); BMC Pediatrics
Associations of arterial thickness, stiffness and blood pressure with brain morphology in early adolescence: A prospective population-based study
Defina at al. (2023); Hypertension
Tags: Causal inference Random-forrest multiple imputation Linear mixed-effect modeling
Arterial Health Markers in Relation to Behavior and Cognitive Outcomes at School Age
Gonçalves at al. (2024); Journal of the American Heart Association
The role of lifestyle factors in the association between early-life stress and adolescent psycho-physical health: Moderation analysis in two European birth cohorts
Defina, Woofenden at al. (2024); Preventive Medicine
Tags: Multi-cohort data harmonization Moderation analysis Causal inference Random-forrest multiple imputation
Prenatal stress, epigenetically-assessed glucocorticoid exposure at birth, and child psychiatric symptoms: A prospective, multi-cohort study
Creasey at al. (2025); Psychoneuroendocrinology
Neuroimaging analysis across diverse ancestries links pleiotropic genetic risk for internalizing disorders to brain development in early adolescence
Xu at al. (in prep);
Early-life stress exposure and intracortical myelination in childhood: a population-based neuroimaging study
Defina, Manzoni at al. (under review);
Tags: Vertex-wise whole-brain analysis Multiple imputation Shiny for Python web application
Longitudinal co-development of depressive symptoms and cardio-metabolic risk factors from childhood to young adulthood
Defina at al. (under review);
Tags: Random-intercept cross-lag panel model Generalized cross-lag panel model Dash web application Causal inference Longitudinal data analysis
Early-life stress exposure and heart morphology in childhood: a prospective population-based study
Defina at al. (in preparation);
Tags: Causal inference Cardiac MRI analysis Multiple imputation Mediation analysis
software
GuRu: a smart variable search tool for Generation R
This web application is a searchable data dictionary for the Generation R study. The backend pipeline includes scraping, cleaning and labelling available data. The search algorithm is powered by a knowledge network based on SNOMED. | Repository
Longitudinal modeling of the co-development of mental and physical health
This web application showcases several modelling approaches addressing causal inference questions in the co-development of mental and physical health. These include cross-lag panel and network analyses (including generalized CLPM and random intercept CLPM) and g-estimation. | Repository
verywise WIZARD
User-friendly web application for visualizing (3D) whole-brain surface vertex-wise statistical maps. | Repository
DeMetRA: Developmental Methylation Risk Atlas
WORK IN PROGRESS: A literature review / atlas tool for developmental MPSs | Repository